Objectives: To describe the concerns and priorities of key stakeholders in a developing country regarding ethical obligations held by researchers and perceptions of equity or “what is fair” for study participants in an HIV/AIDS clinical drug trial. Design: Qualitative study with focus groups. Setting: Teaching and referral hospital and rural health centre in western Kenya. Participants: Potential HIV/AIDS clinical trial participants, clinician researchers, and administrators. Results: Eighty nine individuals participated in a total of 11 focus groups over a four month (...) period. The desire for continued drug therapy, most often life long, following an HIV/AIDS clinical trial was the most common priority expressed in all focus groups. Patients with and without HIV/AIDS also thought subsidisation of drug therapies and education were critical forms of compensation for clinical trial participation. Financial incentives were considered important primarily for purchasing drug therapy as well as obtaining food. Patients noted a concern for the potential mismanagement of any money offered. Clinician researchers and administrators felt strongly that researchers have a moral obligation to participants following a trial to provide continued drug therapy, adverse event monitoring, and primary care. Finally, clinician researchers and administrators stressed the need for thorough informed consent to avoid coercion of study participants. Conclusions: Kenyan patients, clinician researchers, and administrators believe that it would be unfair to stop antiretroviral therapy following an HIV/AIDS clinical trial and that researchers have a long term obligation to participants. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Of all the distinctive features of the Buddhist religion, one of the most neglected is the sangha . Scholars give much attention to the study of texts and commentaries, the analysis of doctrines and the classification of schools. But the core of the Buddhist religion is the sangha , the community of bhikkhus around whose corporate life the religion is moulded. It is the existence and structure of the sangha which has shaped the history of Buddhism, enabled it to take (...) root in new countries, and given it the customs and rituals which have made it a religion rather than a small sect. (shrink)

D. N. MacCormick; XI*—The Obligation of Reparation, Proceedings of the Aristotelian Society, Volume 78, Issue 1, 1 June 1978, Pages 175–194, https://doi.org/10.

D. N. MacCormick; XI*—The Obligation of Reparation, Proceedings of the Aristotelian Society, Volume 78, Issue 1, 1 June 1978, Pages 175–194, https://doi.org/10.

Aristotle's well-known divisions of friendship, those based on utility, pleasure and virtue, are based on the kind of good each provides. It is fairly easy to see what is contributed by utility- and pleasure-friendships, but virtue-friendship presents a special difficulty. Aristotle writes that virtue-friendship occurs between good (virtuous) persons, each of whom is happy because of that goodness. Aristotle also asserts, however, that the good (happy) person, especially the philosopher, is largely self-sufficient, needing little in the way of external goods (...) for his happiness. Such a person is virtuous not only in the moral sense but intellectually, having developed the capacities of the mind to make effective moral decisions and, in the case of the philosopher, to contemplate the most divine of subjects. If that is the case, it is not difficult to see why such a person would not need many utility- or pleasure-friends, but why would he need virtue-friends? What does virtue-friendship contribute to the happiness of one who is already happy? Possible answers to those questions have been provided by a number of commentators, whose views will be considered below. I believe their answers can be classified into three general types of argument: the �opportunity argument�, the �reassurance argument� and the �pleasure argument�. Although all of these have their merits, each has pitfalls. There is another possible answer, an �essentialist argument�, which more accurately describes Aristotle's view. I will argue that virtue-friends come to understand each other's true selves, and each, through the awareness and contemplation of the other, becomes a better human being and, consequently, happier. (shrink)

This paper looks into the known evidence on the origins of the type of argument called the circumstantial ad hominemargument in modern logic textbooks, and introduces some new evidence. This new evidence comes primarily from recent historical work by Jaap Mansfeld and Jonathan Barnes citing many cases where philosophers in the ancient world were attacked on the grounds that their personal actions failed to be consistent with their philosophical teachings. On the total body of evidence, two hypotheses about the roots (...) of the circumstantial ad hominem are considered. One is that it came from Aristotle through Locke. The other is that it may have had separate roots in these ancient philosophical writings that criticized philosophers for not practicing what they preached. (shrink)

Volume 1 presents the texts in new translations by the authors, and these are accompanied by a philosophical and historical commentary designed for use by all readers, including those with no background in the classical world. With its glossary and indexes, this volume can stand alone as an independent tool of study.

Two recently published oral histories highlight the long-term trend concerning the mainstreaming of Objectivism, the political and economic ideas of the libertarian conservative writer and ideologue, Ayn Rand. Scott McConnell’s sympathetic interview collection focuses on supporters and acquaintances from Rand’s active period in the 1960s and 1970s. These supporters and acquaintances include former Australian Prime Minister, Malcolm Fraser, who provides McConnell with his considered views concerning Rand. Gary Weiss’s critical interview collection focusses on her more recent supporters, with one displeased (...) and insightful interviewee to be found in both collections. Weiss’s collection reveals the role played by Objectivists in galvanizing the focus of the populist Tea Party movement. Both oral histories reveal the role played by the media and popular culture in mainstreaming Rand’s views. The review ends by comparing Randolph Stow’s socially responsive individualism as described in his novel 'Tourmaline' with Rand’s transactional individualism as described in 'Atlas Shrugged.'. (shrink)

T. 1. Metodologicheskie osnovanii︠a︡ i modeli, Bogopoznanie i nauchnoe znanie -- t. 2. Chislo. Garmonii︠a︡. Metafizika Sveta -- t. 3. Svet bogoslovskie osnovanii︠a︡ kreatologi.

Equity was first established as a terminus technicus by Aristotle, but the word was initially shaped by Plato in his Statesman. Aristotle considers equity as a necessary criterion of the interpretation of human action, i.e., the ultimate, the particular moral situation, given that law is general, and every moral agent makes different moral choices, since man exhibits a multiplicity of purposes as a being and every person acts on the basis of a variety of moral perspectives and values. Therefore, the (...) task of every judge is to trace the moral choice made by a moral agent, as well as to interpret the law and attribute justice, since, as it is attested, law may be deficient, whereas this does not necessarily apply to justice itself. (shrink)

D N Aspin; Church Schools, Religious Education and the Multi-ethnic Community, Journal of Philosophy of Education, Volume 17, Issue 2, 30 May 2006, Pages 229–24.

In this article I describe the analytic approach adopted by Peters, his colleagues and followers of the ?London line? in the 1960s and 1970s and argue that, even in those times, other approaches to philosophy of education were being valued and practised. I show that Peters and his colleagues later became aware of the need for philosophy of education to become aware of and take in hand a new set of agendas and address the list of substantive issues inherent in (...) the contexts and political considerations beginning to impinge on education in the 1980s and beyond. I argue that there is much to be said for adopting a postempiricist problem-solving approach and point to the ways in which an evolutionary epistemology may be usefully applied to many of the problems of modern educational discourse. But I also seek to show how the abiding axiological concerns of Peters may still serve as the substantive background and definition of the value emphasis of the aims and directions in which philosophers of education are currently still working. (shrink)